What is the Role of Collagen in Wound Healing?

In a healing wound, a cascade of events occurs and is broken into what is known as the phases of wound healing. These include platelet accumulation, inflammation, fibroblast proliferation, cell contraction, angiogenesis and re-epithelialization. This cascade ultimately leads to scar formation and wound remodelling. Collagen plays an important role in each of these phases of wound healing due to its chemotactic role. It attracts cells such as fibroblasts and keratinocytes to the wound. This encourages debridement, angiogenesis and re-epithelialization. A chronic wound is stalled at one of these healing stages. This usually occurs during the inflammatory phase and is linked to elevated levels of matrix metalloproteinase (MMPs) in the wound. In normal wound.